The current proposal is that Sem1 functions to hold and stabilise Sac3 and Thp1 together. It is probable that Sem1 operates analogously in other complexes that contain PCI folds.
Within the 19S proteosome lid, Sem1 is found to be associated with Rpn7 and Rpn3 (two PCI-proteins), forming a subcomplex with Rpn12. This suggests that Sem1 stabilises Rpn7 and Rpn3 in an analogous manner to the Sac3-Thp1-Sem1 complex. Recent evidence suggests that this is true because Sem1 deletions results in destabilisation of the 19S proteosome.
- Written by Xiao Xiao Han
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