- Ellisdon, A.M., Dimitrova, L., Hurt, E., and Stewart, M. (2012). Structural basis for the assembly and nucleic acid binding of the TREX-2 transcription-export complex. Nature Structural & Molecular Biology 19, 328-U390.
- Brickner, D., Cajigas, I., Fondufe-Mittendorf, Y., Ahmed, S., Lee, P., Widom, J., and Brickner, J. (2007). H2A.z-mediated localization of genes at the nuclear periphery confers epigenetic memory of previous transcriptional state. Plos Biology 5, 704-716.
- Cabal, G., Genovesio, A., Rodriguez-Navarro, S., Zimmer, C., Gadal, O., Lesne, A., Buc, H., Feuerbach-Fournier, F., Olivo-Marin, J., Hurt, E., et al. (2006). SAGA interacting factors confine sub-diffusion of transcribed genes to the nuclear envelope. Nature 441, 770-773.
- Fischer, T., Rodríguez-Navarro, S., Pereira, G., Rácz, A., Schiebel, E., and Hurt, E. (2004). Yeast centrin Cdc31 is linked to the nuclear mRNA export machinery. Nat Cell Biol 6, 840-848.
- García-Oliver, E., García-Molinero, V., and Rodríguez-Navarro, S. (2012). mRNA export and gene expression: The SAGA-TREX-2 connection. Biochim Biophys Acta 1819, 555-565.
- Jani, D., Lutz, S., Marshall, N.J., Fischer, T., Köhler, A., Ellisdon, A.M., Hurt, E., and Stewart, M. (2009). Sus1, Cdc31, and the Sac3 CID region form a conserved interaction platform that promotes nuclear pore association and mRNA export. Mol Cell 33, 727-737.
- Nousiainen, H.O., Kestilä, M., Pakkasjärvi, N., Honkala, H., Kuure, S., Tallila, J., Vuopala, K., Ignatius, J., Herva, R., and Peltonen, L. (2008). Mutations in mRNA export mediator GLE1 result in a fetal motoneuron disease. Nat Genet 40, 155-157.
- Zhang, M., Wang, Q., and Huang, Y. (2007). Fragile X mental retardation protein FMRP and the RNA export factor NXF2 associate with and destabilize Nxf1 mRNA in neuronal cells. Proc Natl Acad Sci U S A 104, 10057-10062.
- Ellisdon, A.M., Dimitrova, L., Hurt, E., and Stewart, M. 3T5V (Sac3:Thp1:Sem1 complex) (RCSB Protein Data Bank).
The conserved TREX-2 transcription-export complex plays a vital role in gene expression. It is responsible for the coupling of transcription and nascent mRNA processing with the recruitment of export factors to the nuclear pore complex, thus facilitating mRNA export into the cytoplasm. It also contributes to transcriptional memory and genomic stability.
Tamara Casteels and Xiao Xiao Han
References
Subscribe to:
Posts (Atom)
No comments:
Post a Comment